INFLUENCE OF CORONAVIRUS INFECTION ON VASCULAR REMODELING PARAMETERS IN PATIENTS WITH ARTERIAL HYPERTENSION

Abstract

Objective: to evaluate the effect of COVID19 on arterial stiffness parameters and microalbuminuria (MAU) baseline and in dynamics against the background of antihypertensive therapy (AHT) in patients with arterial hypertension (AH). Design and method: 74 male and female patients with I-III degree of AH (ESH/ESC, 2018) were included in the study. Age was 53.54±1.92, duration of AH was 8.61.2 groups were identified: 1stgroup with AH who had suffered COVID19, no more than a month (N=42) and 2ndgroup with AH not suffered COVID19 (N=32).Vascular stiffness was determined by applanation tonometry using SphygmoCor apparatus (AtCor Medical, Australia); central systolic BP (CSBP), central diastolic BP (CDBP), central pulse pressure (CPP), aortic augmentation (AA), augmentation index (AIx), pulse wave velocity (PWV) were studied. The level of MAU was determined by enzymatic analysis on the biochemical analyser Daytona TM by Rendox (UK), which allows estimating MAU within the range of 30-300 mg/l and higher. The study was conducted before and after 6 months of AHT.p<0.05. The results are presented as μ±SD Results: The level ofMAU in 2ndgroup being 25,5±20,3 mg/l, in 1stgroup being 32,8±27,9 mg/l, but the difference was not significant (p>0,05). There was a significant decrease of MAU level in group I of patients: from 32,8±27,9 mg/l to 20,1±19,2,4 mg/l in dynamics (p<0,02). In 1st group, cSBP decreased from 154.86±24.11 to 134.38±13.9 mmHg (p<0.001) and in 2nd from 163.84±19.87 to 139.47±19.41 mmHg (p<0.001); cPP in 1stgroup decreased from 74.79±22.02 to 53.67±13.32 mmHg (p<0.001) and in 2ndgroup- from 78.84±14.48 to 54.71±12.46 mmHg (p<0.001). (p<0.001) and in 2ndgroup from 78.84±14.48 to 54.71±12.46 mmHg (p<0.001); PWV in 1stgroup decreased from 10.6±2.3 to 9.32±2.21 m/s (p<0.05) and in 2nd from 11.21±3.02 to 9.89±2.12 m/s (p<0.001). AA was significantly reduced only in 2nd: 19.24±7.67 mmHg before and 14.31±7.57 mmHg after(p<0.02) compared to 1stgroup: 15.67±6.97 before and 14.5±6.08 mmHg after treatment (p>0.05). Conclusions: The analysis of central haemodynamics and arterial stiffness parameters revealed positive dynamics of 6-month AHT in both studied groups of patients with advantage in the 2ndgroup. AA index significantly decreased only in the 2ndgroup. The level of MAU initially exceeded normal values in the 1stgroup