Abstract
The low molecular fraction (below 5 kDa) was extracted from cord blood by ultrafiltration. It has been shown that the cord blood fraction possesses antiulcer activity on the model subchronic stomach ulcer. The cord blood fraction injections caused a significant reduction in the area of ulcer lesions and promoted recovery of microcirculation, thickness, and structure of gland layer, which was accompanied by a decrease in leucocytes infiltration and an increase in glycosaminoglycans synthesis. That resulted in a faster recovery of mucus membrane of stomach as compared withActovegin. Application of the cord blood fraction in animals with stomach ulcer normalized the alkaline phosphatase activity and thiobarbituric acid-active product content. Gel-penetrating chromatography showed that the patterns of the low molecular substances from cord blood andActovegindiffered both qualitatively and quantitatively.
Highlights
At present, ulcerative disease of stomach and duodenum is one of the most widespread morbi of the digestive apparatus
Mechanisms of ulcer formation are diverse. Both ulcerogenesis and healing of ulcerative defects proceed against a background of significantly decreased cell energy levels owing to abnormalities of microcirculation, which accompany evident inflammatory changes in mucous coat of stomach [1]
The administration of medicines designated for the elimination of bioenergy disorders, reduction in inflammatory cell infiltration, and recovery of mucous coat microcirculation is among new approaches to the treatment of ulcerative disease
Summary
Ulcerative disease of stomach and duodenum is one of the most widespread morbi of the digestive apparatus. Both ulcerogenesis and healing of ulcerative defects proceed against a background of significantly decreased cell energy levels owing to abnormalities of microcirculation, which accompany evident inflammatory changes in mucous coat of stomach [1]. The administration of medicines designated for the elimination of bioenergy disorders, reduction in inflammatory cell infiltration, and recovery of mucous coat microcirculation is among new approaches to the treatment of ulcerative disease. Its pharmacological action is based on the improvement in glucose transport and oxygen uptake in tissues The latter results in activation of aerobic oxidation, which enhances the cell energy potential. Under conditions of tissue hypoxia caused by microcirculation abnormalities Actovegin contribute to recovery of capillary network due to neogenic vessels [2]
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