Abstract
Polymeric hydrogels are receiving much attention in the past few years, as intelligent materials due to their properties for biomaterials. In this work, hydrogels of poly(N-2-vinil-pirrolidone) (PVP) containing chitosan and clay nanoparticles were obtained and characterized for glucantime drug delivery. The matrixes were crosslinked by gamma irradiation process with doses of 25kGy. Hydrogels morphologies were observed by a Scanning Electron Microscope (SEM). The structural properties of the network were determined by gel fraction and swelling kinetic at 22°C to study the capacity of water retention and, finally, drug delivery tests were performed “in vitro”. The system showed higher gel fraction for the matrix with 1.0% of clay. In this case, besides the interactions of clay ions with PVP, there were interactions of chitosan with PVP. The results of glucantime delivery at the chitosan/PVP and clay system were discussed.
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