Interaction of Chitosan with Hydrogel of Poly(Acrylic Acid) and Preparation of Encapsulated Drugs

Yin Jing Bo,Zauresh S Nurkeeva,Victor A Kan,Grigoriy A Mun,Yulia R Gabdulina,Vitaliy V Khutoryanskiy

doi:10.18321/ectj565

Abstract

The complexation of linear chitosan with hydrogel of poly(acrylic acid) was studied in acetic acid solutions. It was found that the complexation is accompanied by contraction of hydrogel samples with formation of turbid layer on their surface. The dynamic changes of swelling ratio of poly(acrylic acid) hydrogel in course of the interaction with chitosan are interpreted from the diffusion theory point of view considering the properties of double electric layer on hydrogel-solution boundary. The FTIR spectroscopy method revealed the electrostatic mechanism of interaction between poly(acrylic acid) hydrogel and chitosan. The spectrum of polycomplex shows the bands, which are characteristic for both poly(acrylic acid) (1725, 1450, 1249 cm-1) and chitosan (1648, 1536, 1165, 1091, 1023 cm-1) confirming the sorption of the later polymer by hydrogel of poly(acrylic acid). The possibility of encapsulation of antibiotic levomycetin into polycomplex hydrogels as well as its release from the capsules has been studied. It was found that the maximal value of the drug released from the polycomplex capsule is achieved after the longer period in comparison with control experiment with its release from pure PAA hydrogel. It was shown that the interpolymer interactions between oppositely charged linear polymers and hydrogels could be successfully used for preparation of encapsulated forms of various physiologically active substances.

Highlights

Chitosan is a cationic polymer that is produced by deacetylation of chitin, a naturally abundant mucopolysaccharide, and the supporting material of crustaceans, insects, etc
In the present work we have studied the interaction of chitosan with hydrogel of poly(acrylic acid) and demonstrated the possibility of encapsulation of antibiotic drug levomycetin into polyelectrolyte complexes (PEC)
The hydrogels of poly(acrylic acid) (PAA) were immersed into solutions of chitosan with different concentrations

Summary

Introduction

Chitosan is a cationic polymer that is produced by deacetylation of chitin, a naturally abundant mucopolysaccharide, and the supporting material of crustaceans, insects, etc. A cationic nature of chitosan can be utilized for modification of its properties by interactions with various anionic polymers and preparation of polyelectrolyte complexes. A number of studies were done on the interaction between chitosan and different poly(carboxylic acids) in aqueous solutions [3,4,5,6,7,8]. Some of the polyelectrolyte complexes (PEC) based on chitosan demonstrated good drug release properties [9,10,11]. In the present work we have studied the interaction of chitosan with hydrogel of poly(acrylic acid) and demonstrated the possibility of encapsulation of antibiotic drug levomycetin into PEC. In solutions of higher chitosan concentration the macromolecules of linear polymer penetrate into the gel already in the first stage of the interaction and only contraction is observed

Results and discussion

Encapsulation and release of levomycetin from polycomplexes

Conclusion