Abstract
Recognized for various beneficial actions, propolis can be differentiated according to its origin. Red propolis, discovered in the northeast of Brazil, offers a strong antioxidant action. Nanoparticles are an innovative tool in the pharmaceutical field, as they help in efficient drug delivery. This study aimed to use red propolis nanoparticles in dogs and evaluate their action based on hematological and biochemical results. Eight healthy adult dogs (bodyweight, 6–27 kg) received 50 mg/animal of polymeric nanoparticles with 20% red propolis extract in a capsule, orally, once a day. Blood samples were collected weekly (five times), and hematologic, hepatic, and renal evaluations were performed. No significant changes were observed, except for alkaline phosphatase, which showed a significant reduction over time. This study in healthy adult dogs did not verify any hematologic, renal, or hepatic adverse effects of daily oral red propolis polymeric nanoparticles (capsules) administration. The results suggest a potential beneficial effect on the liver.
Highlights
The health benefits and biological activities of propolis have been known for a long time (Pasupuleti et al, 2017)
Silva et al (2008) identified the relative percentages of isoflavonoids 3-hydroxy-8,9dimethoxypterocarpan and medicarpin in Brazilian red propolis (BRP). They demonstrated that the Dalbergia ecastophyllum (L) Taub. (Leguminose) resin exhibits important biological
All dogs were considered healthy according to clinical examination, blood count cells, and normal renal and liver biochemical parameters
Summary
The health benefits and biological activities of propolis have been known for a long time (Pasupuleti et al, 2017). The Brazilian red propolis (BRP) has a unique composition and originates in the Alagoas state mangroves (do Nascimento et al, 2016). It can be found in beehives along the sea and river shores of five states of northeast Brazil. The characteristic red color of BRP is an atypical mix of dark yellow and brown tones, usually seen and derivates from resinous exudates of Dalbergia ecastophyllum (L) Taub. Silva et al (2008) identified the relative percentages of isoflavonoids 3-hydroxy-8,9dimethoxypterocarpan and medicarpin in BRP. They demonstrated that the Dalbergia ecastophyllum (L) Taub. They demonstrated that the Dalbergia ecastophyllum (L) Taub. (Leguminose) resin exhibits important biological
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