Influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations

John Oluwasogo Ayorinde,Michael Ayodele Odeniyi,Oluwatoyin Adepeju Odeku,Oludele Adelanwa Itiola

doi:10.1590/s1984-82502011000400022

John Oluwasogo Ayorinde, Michael Ayodele Odeniyi + Show 2 more

Open Access

https://doi.org/10.1590/s1984-82502011000400022

Copy DOI

Abstract

The influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations were studied using a novel gum from Albizia zygia. Tablets were produced from diclofenac formulations containing corn starch, lactose and dicalcium phosphate. Formulations were analyzed using the Heckel and Kawakita plots. Determination of microbial viability in the formulations was done on the compressed tablets of both contaminated and uncontaminated tablets prepared from formulations. Direct compression imparted a higher plasticity on the materials than the wet granulation method. Tablets produced by wet granulation presented with a higher crushing strength than those produced by the direct compression method. Significantly higher microbial survival (p< 0.05) was obtained in formulations prepared by direct compression. The percent survival of Bacillus subtilis spores decreased with increase in binder concentration. The study showed that Albizia gum is capable of imparting higher plasticity on materials and exhibited a higher reduction of microbial contaminant in the formulations. The direct compression method produced tablets of reduced viability of microbial contaminant.

Highlights

Direct compression is highly efficient, less laborious, and increasingly becoming more popular than both compression granulation and wet granulation methods in the manufacturing of tablets
The results further show that, in all the formulations, the percent survival of Bacillus subtilis spores decreased with increase in binder concentration and formulations containing Albizia gum exhibited a higher reduction of viability of the microbial contaminant than those containing gelatin
The study showed that Albizia gum is capable of imparting higher plasticity and improving the softness of materials as evidenced by lower values of Py and Pk in the formulations containing Albizia gum than those containing gelatin

Summary

Introduction

Direct compression is highly efficient, less laborious, and increasingly becoming more popular than both compression granulation and wet granulation methods in the manufacturing of tablets. Few drug powders can be tabletted by the direct compression method, while most drugs need the incorporation of other substances referred to as tablet excipients in order to achieve satisfactory properties such as strength, disintegration and dissolution times. One such excipient is the binding agent. The process of formation of these solid bonds is capable of exerting a lethal effect on microbial contaminants during tabletting (Ayorinde, Itiola, 2010)

Methods

Results

Conclusion