A COMPREHENSIVE REVIEW ON SUSTAINED RELEASE MATRIX TABLETS: A PROMISING DOSAGE FORM

Agarwal Prakhar,Akhtar Semimul

doi:10.22270/ujpr.v3i6.222

Abstract

Oral ingestion is most convenient and commonly employed route of drug delivery due to its ease of administration, least aseptic and flexibility in the design of dosage form. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance delivery. Different types of extended release matrix tablet have been explained briefly along with the various formulation which mainly by wet granulation or direct compression method or by dispersion of solid particle within a porous matrix formed by using different polymers. Matrix controls the free rate of drug. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.

Highlights

IntroductionThe extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases
Prakhar Agarwal*, Semimul Akhtar Department of Pharmacy, Shri Ram Murti Smarak College of Engineering & Technology, Bareilly, UP, India
Matrix tablets may be formulated by wet granulation or direct compression methods by dispersing solid particles within a porous matrix formed of hydrophilic and hydrophobic polymers[6,7,8,9]

Summary

Introduction

The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. In addition to the difficulty of therapeutic regimens, the cost of therapy and local or systemic side effect of the dosage form This issue can be set out to some degree by administering sustained release drug delivery system. Ii) Reduced 'see-saw' fluctuation Drug concentration in the systemic circulation and tissue compartments show „see saw‟ pattern frequently when the drug administration in conventional dosage form. The sizes of these variances fundamentally rely upon drug kinetics such as the rate of absorption, distribution, elimination and dosing intervals[15]. Economy The initial unit cost of sustained release products is typically more than that of conventional dosage form because of the special nature of these compounds but importantly average cost of treatment over an prolong period of time may be less[19]

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