Abstract
The influence of angiotensin II (ANG II) on sympathetic ganglionic transmission was examined in the in situ, normally perfused, superior cervical ganglion in pentobarbitone-anaesthetized rabbits. Compound action potentials were evoked in the external carotid nerve by repetitive electrical stimulation of the decentralized preganglionic cervical sympathetic nerve (supramaximal intensity, 1 ms, 0.5 Hz). A continuous partial nicotinic block was maintained by intravenous infusion of hexamethonium. The converting enzyme inhibitor captopril was infused to prevent the endogenous generation of ANG II. Graduated intravenous infusion of ANG II brought about graduated increases in the height of the S 2 potential; the threshold rate of infusion for this effect was 40 ng min -1. At this infusion rate, the plasma concentration of ANG II was estimated to lie between 80 and 600 pg ml -1. While ANG II can modify sympathetic ganglionic transmission, it is unlikely that it has any effect at physiological plasma concentrations of circulating ANG II reported for the rabbit (2–80 pg ml -1).
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