Carotid bifurcation pressure modulation of spontaneous activity in external and internal carotid nerves can occur in the superior cervical ganglion

Abstract

Previous reports have suggested that a peripheral pressure-modulated reflex operates at the level of the superior cervical ganglion to alter evoked activity in the postganglionic nerves of the ganglion in both the cat and rabbit. In the present study we have examined if spontaneous activity of the external and internal carotid nerves of the rabbit superior cervical ganglion can be modulated during changes of the carotid bifurcation pressure (CBP), independent of central nervous system (CNS) integration. For external carotid nerve recordings increases in CBP resulted in a reduction in spontaneous activity while decreases in CBP were associated with an increase in spontaneous activity. For internal carotid nerve recordings similar effects were observed in the majority of recordings although a subset of recordings showed opposite effects or were not responsive to changes in pressure. To determine if vagus nerve afferents contribute to the observed pressure-modulated spontaneous activity effects, the influence of CBP on external carotid nerve recordings was examined before and after section of the vagus nerve rostral to the nodose ganglion. We found that even following section of the vagus nerve the external carotid nerve response to an increase in pressure remained intact. These results demonstrate that, after section of centrally-projecting afferent pathways from the carotid bifurcation to the CNS, changes in CBP can still modify spontaneous sympathetic activity of the rabbit superior cervical ganglion. The data reinforce previous findings related to evoked responses in the postganglionic nerves and also suggest that a pressure-modulated reflex, integrated at the level of the superior cervical ganglion, can influence ongoing sympathetic nervous outflow from the superior cervical ganglion in the rabbit.