Abstract
Cognitive dysfunction is a common disease in aging population. This study aims to compare the influence of different degrees of anemia on the cognitive function of patients undergo hysteromyoma surgery. Sixty-one patients aged 18–60 years who underwent uterine fibroid surgery in the Second Affiliated Hospital of Shantou University Medical College from March 2019 to December 2020 were selected for this study. Patients were divided into three groups: group normal (Group N, patients have no anemia), group of mild anemia (Group Mi, patients have mild anemia) and group of moderate anemia (Group Mo, patients had moderate anemia). Combined spinal and epidural anesthesia were administered. Cognitive function tests were performed 1 day before the surgery and repeated at the 5th and 30th days after surgery. Peripheral venous blood samples from patients were collected before the surgery, right after surgery and at the 24th and 72nd hours after surgery. The contents of S-100β, IL-6, TNF-α and IL-1β in serum samples were determined by ELISA. It was found that there were no significant differences in general characteristics of patients among Group N, Group Mi and Group Mo (p > 0.05). Nine patients developed postoperative cognitive dysfunction after surgery, and the incidence was 14.75% (9/61). The incidence of postoperative cognitive dysfunction (POCD) was 40% in Group Mo, which was higher than that in Group N and Group Mi. The difference was statistically significant (p < 0.05). Inflammatory factors in patients with POCD were higher in post-surgery than before-surgery (p < 0.05), while there was no statistical significance in the difference of inflammatory factors of patients without POCD before and after surgery (p > 0.05). Taken together, this study suggested that moderate anemia could be a risk factor of POCD in patients undergoing hysteromyoma surgeries. This study will help surgeons developing measures for preventing the occurrence of POCD.
Highlights
Postoperative Cognitive Dysfunction (POCD) is a concept that was formally introduced in 1988 by the International Study Group on Postoperative Cognitive Dysfunction, a group of 13 medical centers in eight countries (Moller et al, 1998)
We examine whether chronic anemia in patients with uterine fibroids, which is associated with varying degrees of anemia, contributes to the development of postoperative cognitive dysfunction (POCD)
Patients included in the study were divided into three groups according to the preoperative hemoglobin level of the patients, including normal group (Group N, patients who had preoperative hemoglobin levels over 110 g/L), mild anemia group (Group Mi, patients who had preoperative hemoglobin level between 90 and 110 g/L) and moderate anemia group (Group Mo, patients who had preoperative hemoglobin levels between 60–90 g/L)
Summary
Postoperative Cognitive Dysfunction (POCD) is a concept that was formally introduced in 1988 by the International Study Group on Postoperative Cognitive Dysfunction, a group of 13 medical centers in eight countries (Moller et al, 1998). This concept describes a common central nervous system complication that occurs after anesthesia and surgery, and is characterized by brain dysfunction and cognitive abnormalities that occur within days to months after anesthesia and surgery (Cascella et al, 2018). The pathogenesis of POCD has not yet been clearly defined, and few study has been conducted to develop clinical treatment options for patients with POCD.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
