Abstract
ABSTRACT The time-response relationship between a single intravenous injection of adrenocorticotropic hormone (ACTH) and thyroid-stimulating hormone (TSH), and their effect on the initial accumulation of radioiodine in the thyroid, was studied in normal, adrenalectomized and adrenalectomized-hypophysectomized patients. The radioiodine uptake increased significantly in adrenalectomized patients 1/2, 1, 2 and 6 hours after intravenous injection of 25 IU ACTH (Acton, Ferring) and then returned to the initial level. Almost identical results were obtained from experiments using highly purified ACTH preparations from different laboratories. On the other hand, hypophysectomized, adrenalectomized- hypophysectomized and patients with normal endocrine function showed no increase in the uptake of radioiodine. Daily intramuscular injections of 25 IU ACTH (Acton prolongatum, Ferring) also produced a slight increase of the radioiodine accumulation during the period of observation (6 days). The effect of ACTH on the upt...
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