Abstract
Thermophilic microorganisms which can colonize at extreme ecological niches are known as extremophiles. Because of their capacity to withstand high temperatures, enzymes from these organisms are relatively heat stable. The versatile enzyme properties of these organisms make them excellent candidates in biotechnology. In general, fungi have been widely used for the production of proteins and enzymes, since they can grow rapidly in a low cost media and they secrete proteins into the extra-cellular medium. Recently, these organisms have also been used in large scale fermentation as host for the expression of heterologous proteins in industrial applications. However, little is known about the regulation and genetic manipulations of these fungi. We have previously shown the regulation of gene expression in a thermophilic fungus, Thermyces lanuginosus, using an inducible invertase system. The aim of this review is to elucidate the recent advances of thermophilic fungi, and their implications in industrial applications are discussed.
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