Abstract
The response of the dental pulp to a carious lesion may involve both specific and nonspecific inflammatory reactions. Nonreversible tissue damage as well as repair and healing can result. Information is presented regarding possible mechanisms involved in the development of pulpitis in relation to infection in dentin. Data from animal experiments are presented; both the immediate and late responses of the pulp tissues are studied. These pulpal responses were produced by bacterial and antigenic substances allowed to penetrate through intact but exposed dentin.
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