Abstract
To compare the inflammatory reaction and the growing resistance of the abdominal wall with the use of poliglecaprone meshes and polypropylene meshes associated with poliglecaprone in the correction of abdominal defects. Seventy-seven Wistar rats were divided into three groups: CG (non-operated animals: EG (polypropylene mesh) and UG (polypropylene and poliglecaprone mesh). A muscular and aponeurotic defect was formed and treated according to the group. Evaluations were made after 4, 7, 14, 28 and 56 days. The resistance and inflammatory pattern were studied. There was a gradual and significant gain in resistance, regularly in the EG and irregularly in the UG, which was lower on the 14th day (p=0.008). The inflammatory reaction was acute and more intense in the UG on the fourth day. At all other times, the inflammatory pattern was acute to chronic, similar in both groups, with minimum intensity on the 56th day. The greater resistance offered by the polypropylene mesh was regular and ascending, stabilizing on the 28th day, while that of the polypropylene/poliglecaprone was not even. In the end, the resistances were similar. The inflammatory response was greater in the UG on the fourth day and similar at all other times.
Highlights
Incisional hernias, known as ventral hernias or eventrations, occur when tissues protrude through openings or areas of an abnormal abdominal wall due to a trauma or wound[1]
The study was analyzed by the Ethics Committee on the Use of Animals in Health Sciences of the Federal University of Paraná (UFPR) and assigned Process number 23075.038580/201281 and approved as case 650, on 1 November, 2012, R.O. 10/2012, in accordance with Federal Law 11.794, of 8 October, 2008, which establishes the procedures for the scientific use of animals and guidelines from the Brazilian College of Animal Experiments (COBEA)
A microscopic examination showed on the fourth day that in the UG the acute inflammatory reaction was predominant (p=0.0454)
Summary
Incisional hernias, known as ventral hernias or eventrations, occur when tissues protrude through openings or areas of an abnormal abdominal wall due to a trauma or wound[1]. They occur following a laparotomy with a frequency estimated between 10% and 20%2. Between 31% and 55% of repairs for hernias without prostheses can lead to a relapse[3,4]. The first surgery to correct hernias using polypropylene meshes was performed by Usher et al.[6]. Surgical meshes are currently considered the gold standard treatment for herniorrhaphies[7], with the polypropylene mesh being the most commonly used[4]
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