Inflammatory Markers in Chronic Kidney Disease

Abstract

Background: Despite recent advances in chronic kidney disease (CKD) and end-stage renal disease (ESRD) management, morbidity and mortality in this population remain exceptionally high. Persistent, low-grade inflammation has been recognized as an important component of CKD, playing a unique role in its pathophysiology and being accountable in part for cardiovascular and all-cause mortality, as well as contributing to the development of protein-energy wasting. Material and methods; This study was conducted on CKD patients attending OPD & IPD of Civil Hospital tarn taran. The participants having age more than 18 years & less than 60 years. We assessed 120 individuals out of 60 are normal healthy individuals comprising the control groups & rest 60 is of CKD cases. Serum CRP (mg/dl) concentration was measured by Latex agglutination test & ESR (mm/hour) was measured by Wintrobe’s method. Serum Creatinine (mg/dl), Urea (mg/dl) & Uric acid (mg/dl) concentration was measured by Modified Jaffe’s method, Urease & Uricase method respectively. Results: - In the present study, serum CRP & ESR was increased in CKD patients. The mean serum CRP levels of CKD patients & controls were 33.55 ± 22.8 & 2.07 ± 6121 respectively (p< 0.001), highly significant result was observed. Mean level of serum ESR (40.25 ± 14.93) of cases shows statistical significant differences as compared with the mean of serum ESR of controls (13.50 ± 3.421). Conclusion: - CRP & ESR are the markers used to evaluate kidney disease, however, each of these has its own limitation. The use of these inflammatory biomarkers may better assess overall patients’ risk & be able to stage patients more appropriately.