Abstract
BackgroundThe prevalence of abdominal obesity among women in UAE is exceptionally high. However, its impact on cardiovascular health has not been adequately investigated. The aims of this study were to investigate: (1) correlations between inflammatory and oxidative biomarkers vs. anthropometric and metabolic measures; (2) rates of dyslipidemia, diabetes, and hypertension and (3) risks of cardiovascular disease.MethodsOne hundred ten “healthy” overweight/obese Emirati women attending nutrition counselling clinics were randomly recruited. All participants had completed questionnaire, physical examination and laboratory assessment.ResultsThe participants’ mean ± SD of age, body mass-index, waist circumference were 39 ± 9 years, 34 ± 6 kg/m2 and 100 ± 13 cm respectively. Among the studied women 45 % met diagnostic criteria for metabolic syndrome showing a positive correlation of hsCRP with BMI (p = 0.002), body fat (p = 0.002) and waist circumference (p = 0.018). There was positive correlation of IL-6 with waist circumference (p = 0.019) and adiponectin with HDL (p = 0.007). Prevalence of HDL <1.3 mmol/L or triglycerides ≥1.7 mmol/L were 82 %, dysglycemia 31 %, and hypertension 27 and 37 % of women had either ‘high’ or ‘moderate’ calculated cardiovascular 10-year risk score.ConclusionThe levels of inflammatory and oxidative stress markers were highly prevalent among overweight/obese Emirati women and this may predispose to increasing cardiovascular risks at relatively young age. Thus effective strategies to impact cardiovascular burden and conducting outcome studies assessing the increased risk of cardiovascular disease and addressing obesity prevention among women are urgently needed.
Highlights
The prevalence of abdominal obesity among women in United Arab Emirates (UAE) is exceptionally high
The term ‘central or abdominal obesity’ has recently emerged as a predictor of cardiovascular disease [5, 6]. This anthropometric variable is determined by measuring the waist circumference, which correlates with visceral fat better than the body mass-index (BMI) [7]
The level of adiponectin is found in the current study to negatively correlate with triglyceride level (p = 0.006), positively correlate with high-density lipoprotein-cholesterol (HDL) (p = 0.007) in women who do not have metabolic syndrome, and negatively correlate with waist circumference in women who have metabolic syndrome (Table 3)
Summary
The prevalence of abdominal obesity among women in UAE is exceptionally high. its impact on cardiovascular health has not been adequately investigated. The aims of this study were to investigate: (1) cor‐ relations between inflammatory and oxidative biomarkers vs anthropometric and metabolic measures; (2) rates of dyslipidemia, diabetes, and hypertension and (3) risks of cardiovascular disease. The rising trends of obesity and diabetes in United Arab Emirates (UAE) impose serious cardiovascular health concerns [1]. The term ‘central or abdominal obesity’ has recently emerged as a predictor of cardiovascular disease [5, 6]. This anthropometric variable is determined by measuring the waist circumference, which correlates with visceral fat better than the body mass-index (BMI) [7]. Central obesity is a cardinal feature of the metabolic syndrome [9], which is defined
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