Abstract
Acute primary angle-closure (APAC) eyes show an early ‘acute inflammatory’ condition, while the inflammation condition has not been fully elucidated in the development of primary angle-closure glaucoma (PACG). To evaluate the roles of inflammatory cytokines in the pathogenesis of PACG, this cross-sectional study involved 40 eyes of 32 PACG patients who required trabeculectomy and 24 eyes of 24 patients who required cataract surgery. The aqueous humor samples were collected at the time of surgery. Fifteen inflammatory cytokines were detected using the multiplex bead immunoassay technique, and the clinical information was recorded for the correlation analysis. Eight of the 15 cytokines were all detectable in both groups, including granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), macrophage inflammatory protein (MIP)-1β, and vascular endothelial growth factor (VEGF). When compared with the cataract patients, the MCP-3, MDC, and VEGF levels were elevated in the PACG patients, while the MCP-1 and MIP-1β levels were decreased. However, the G-CSF, IL-6, and IL-8 levels were similar between the two groups. The MCP-1 concentration was elevated accordingly as the disease progressed in the PACG patients. Our results suggest the PACG eyes retained a ‘mild inflammation’ condition in the aqueous humor, and MCP-1 may play an important role in the progression of this disease.
Highlights
Primary angle-closure glaucoma (PACG) is one of the main types of glaucoma leading to irreversible blindness, with a 1.1% prevalence rate in the Asian population [1]
Only eight cytokines were all detectable in both groups, including granulocyte colony-stimulating factor (G-CSF), IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1), monocyte chemotactic protein-3 (MCP-3), macrophage-derived chemokine (MDC), macrophage inflammatory protein-1β (MIP-1β), and vascular endothelial growth factor (VEGF)
The monocyte chemotactic protein (MCP)-3 (P = 0.012), MDC (P < 0.001), and VEGF (P = 0.033) concentrations were significantly higher in the PACG group than in the cataract group, while the MCP-1 (P = 0.021) and macrophage inflammatory protein (MIP)-1β (P = 0.022) concentrations were significantly decreased in the aqueous humor of the PACG patients
Summary
Primary angle-closure glaucoma (PACG) is one of the main types of glaucoma leading to irreversible blindness, with a 1.1% prevalence rate in the Asian population [1]. The inflammatory conditions in the different disease stages, PAS extents and the influences of different anti-glaucoma drug choices were analyzed This cross-sectional study recruited 32 PACG patients who required trabeculectomy [14] and 24 patients requiring cataract surgery from the Zhongshan Ophthalmic Center at Sun Yat-sen University in Guangzhou, China. The exclusion criteria were any history of trauma, uveitis, or other intraocular or systemic inflammatory diseases; pre-existing ocular diseases, such as retinal artery/vein occlusion, diabetic retinopathy, and age-related macular degeneration; and any intraocular intervention, including paracentesis Those eyes that required a trabeculectomy combined with cataract surgery or cataract surgery at a late date within the study period were excluded. P < 0.0071 was accepted by Bonferroni correction for multiple comparisons
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call