INFLAMMATORY AND ANTI-INFLAMMATORY MECHANISMS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE, CHRONIC CORONARY SYNDROME AND THEIR COMBINATION

Abstract

Objective – to compare the levels of serum Sirtuin-1(SIRT1) and high-sensitivityC-reactive protein in patients with сhronic obstructive pulmonary disease (COPD) andсhronic coronary syndrome (CCS) during their isolated and combined course.Materials and methods. Sixty patients with diagnoses of сhronic obstructive pulmonarydisease (COPD), сhronic coronary syndrome (CCS), COPD in combination with CCS,and 10 practically healthy people (control group), were involved into the study.The comparison of data between samples was carried out according to the Student’st-test, the relationship between indicators was investigated using the Fisher correlationcoefficient. The calculations were carried out using Microsoft Excel software.Results. In the group of patients with COPD the level of high-sensitivity C-reactiveprotein constituted 1.47±0.31 mg/dl (p=0.02), in patients with CCS – 1.06±0.23 mg/dl(p=0.02), in patients with COPD, combined with CCS, – 2.13±0.30 mg/dL (p=0.01) thatwas significantly higher than in the control group –0.11±0.02 mg/dL (p=0.03).The results of the study of the SIRT1 level in the blood serum revealed that in the groupof patients with COPD, the level of SIRT1 constituted 5.21±1.16 ng/ml, in patients withCCS – 6.58±1.40 ng/ml, in patients with COPD combined with CCS –2,32±0.73ng/ml,that in all cases it was significantly lower than in the control group – 12.23±1.59ng/ml(р=0.01).Conclusions. Serum levels of SIRT1 were lower and high-sensitivity CRP were higher inpatients with COPD, CCS and in patients with COPD, combined with CCS, in comparisonwith the control group. There is a negative correlative relation in patients with COPD andCCS between the levels of high-sensitivity CRP and SIRT1.