Abstract

Physical training of adolescence may lower the risk for coronary artery disease (CAD) by mitigating inflammation which plays a key role in the pathophysiology of atherosclerosis. PURPOSE: The aim of this study was to determine the effects of 12 weeks of aerobic and resistance training on interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a) and high sensitive C-reactive protein (hs-CRP) in obese middle school boys. METHODS: Subjects were 12-14 year old male students, who were classified into three groups by training type (non-exercise obese group (NE) n=9, aerobic group (AG) n=9, resistance group (RG) n=8). Obesity was defined by the WHO guidelines for the Asia-Pacific Region (BMI > 25.0 kg/m2) Aerobic training consisted of rope jumping, running, cycling exercise and was performed for 40 min/day at 60-70% heart rate reserve for 12 weeks. Resistance training consisted of seven exercises, which included all the major muscle groups, and 2-3 sets of 15 repetitions with 60-70% of one repetition maximum. BMI, IL-6, TNF-a, hs-CRP, and VO2max were assessed at baseline and after 6 and 12 weeks of the program. Data were analyzed by repeated measures ANOVA (a=.05) for the training period training. RESULTS: BMI did not significantly change in any group after 12 weeks. However waist hip ratios (WHRs) of AG were significantly decreased from 0.87±0.07 at baseline to 0.86±0.07, 0.84±0.06 after 6 and 12 weeks respectively (p<.05). After 12 weeks of training, IL-6 was significantly increased in RG (1.45±0.93pg/ml vs. 1.89±0.42pg/ml, p<.05) but did not significantly change in NE and AG. After 12 weeks of training, TNF-a was significantly decreased in AG (9.91±3.34pg/ml vs. 8.43±2.41pg/ml, p<.05) and RG (9.10±2.24pg/ml vs. 8.71±2.80pg/ml, p<.05) with no significant difference seen in NE at any point. VO2max of AG and RG were significantly increased at 6 and 12 weeks vs. baseline (p<.05). However, there were no significant differences in hs-CRP at any time point among the groups. CONCLUSIONS: Although the amounts of changes of IL-6 and TNF-a were not much because of the short training period, obese boys' inflammatory responses after 12 weeks of physical training were beneficial.

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