Abstract 13599: Combined Aerobic and Resistance Exercise Training Decrease Oxidative Stress by Augmenting Antioxidant Potential in Patients with Cardiovascular Disease

Abstract

Introduction: Oxidative stress plays important roles in pathophysiology of atherosclerotic disease. However, little is known about the effects of aerobic exercise and resistance exercise on the oxidant offense and antioxidant defense systems in cardiovascular disease (CVD). Hypothesis: We hypothesized that combined aerobic and resistance exercise training decrease oxidative stress in patient with CVD. Methods: Thirty-two patients with CVD refer to in-hospital cardiac rehabilitation were divided to aerobic exercise (AE) group (n=15) and combined aerobic and resistance exercise (AE+RE) group (n=17). AE sessions consisted of 50 minutes of exercise (anaerobic threshold level), 5 days/week during training period (mean 27 days). Resistance exercise (30% of 1-repetition maximum) was performed 3 days/week before AE sessions. Serum reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) were measured using the FRAS4 (Diacron International, Italy) before and after training period. BAP/d-ROMs ratio was used as an indicator of oxidative stress. Results: No significant differences in baseline values of age, body mass index, exercise tolerance and BAP/d-ROMs ratio were observed between the AE+RE group and the AE group. After training period, exercise tolerance (the AE group: 5.1 ± 1.0 to 5.6 ± 1.0 METs, p<0.01, the AE+RE group: 5.1 ± 1.1 to 5.7 ± 1.0 METs, p<0.01) were significantly increased in both groups. In the AE+RE group, d-ROMs decreased and BAP significantly increased (2173 ± 268 to 2338 ± 182, p<0.05). Consequently BAP/d-ROMs ratio significantly increased (7.3 ± 1.5 to 8.9 ± 3.1, p<0.05) after training period. In the AE group, d-ROMs significantly decreased (374 ± 61 to 347 ± 61, p<0.05), and BAP trends to decreased (2389 ± 201 to 2279 ± 189, p<0.1). Consequently BAP/d-ROMs ratio did not significantly change after training period. BAP/d-ROMs ratio in the AE+RE group were significantly higher than those in the AE group (8.9 ± 3.1 vs 6.8 ± 1.3, p<0.05) after training period. Conclusions: The present findings suggest that combined aerobic and resistance exercise training decrease oxidative stress by augmenting antioxidant potential in patients with CVD.