Infectious and Non-Infectious Sensitisation of Patients with Bronchial Asthma and Chronic Obstructive Pulmonary Disease

Abstract

The study involved 169 people, of which 33 were practically healthy, 69 had bronchial asthma, 24 had bronchial asthma combined with chronic obstructive pulmonary disease, 35 had COPD and 8 had community-acquired pneumonia. We assessed the presence of IgE to tick allergens, dust allergens, and the combined allergens of grass, trees, weeds and flower pollen. We determined the presence of IgE and IgG to the allergens Strept. ?neumon., Haemofil. influenzae, Neisseria ?erflava and Staph. ?ureus. We assessed the presence, multiplicity, severity and combination of sensitisation to the presence of specialised IgE towards infectious and atopic allergens. All study groups displayed sensitisation, including heaslthy people and patients with COPD and community-acquired pneumonia, who did not show clinical allergy symptoms. A statistically significant direct correlation was established between IgG and IgE to Strept. Pneumoniae and Haemofilus influenza in healthy subjects and those with pulmonary conditions. The IgE or IgG reaction to Neisseria perflava and Staph. ?ureus did not show a significant correlation in either healthy or affected subjects.