Analysis of CCR2 chemokine receptor gene polymorphism in patients with bronchial asthma and chronic obstructive pulmonary disease

И И Черкашина ,С Ю Никулина ,М И Воевода ,Н И Логвиненко ,В Н Максимов ,В А Шульман ,В А Шестовицкий ,А А Чернова

doi:10.18093/0869-0189-2013-0-1-20-24

И И Черкашина , С Ю Никулина + Show 6 more

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https://doi.org/10.18093/0869-0189-2013-0-1-20-24

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Journal: Pulmonology	Publication Date: Jan 1, 2013
Citations: 1	License type: cc-by

Affiliation: Novosibirsk State Medical University

Abstract

Summary . The aim of this study was to investigate prevalence of genotypes and CCR2 gene alleles in patients with bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD). We examined 90 BA patients, 72 COPD patients and healthy subjects as controls using standard diagnostic tools for these diseases and molecular analysis. CCR2 chemokine receptor gene polymorphism was investigated in patients with BA and COPD in comparison with healthy subjects. There was not any significant difference in prevalence of genotypes and CCR2 gene alleles in patients with BA or COPD, or in controls. The results have shown an association between rare allele 641 in the CCR2 gene and COPD and a protective role for homozygous genotype 64V/64V of this gene in COPD development. The comparative analysis allowed extension our knowledge about some genetic features of these diseases. The CCR2 chemokine receptor gene polymorphism was associated with COPD but not with BA.

Highlights

We examined 90 bronchial asthma (BA) patients, 72 chronic obstruc tive pulmonary disease (COPD) patients and healthy subjects as controls using standard diagnostic tools for these diseases and molecular analysis
The results have shown an association between rare allele 641 in the CCR2 gene and COPD and a protective role for homozy gous genotype 64V/64V of this gene in COPD development
Глобальная стратегия диагностики, лечения и профилактики хронической обструктивной болезни легких (COLD)

Summary

Оригинальные исследования

И.И.Черкашина 1, С.Ю.Никулина 1, Н.И.Логвиненко 2, В.А.Шульман 1, В.А.Шестовицкий 1, М.И.Воевода 3, В.Н.Максимов 3, А.А.Чернова 1. – ГОУ ВПО "Красноярский государственный медицинский университет им. В.Ф.Войно Ясенецкого", кафедра внутренних болезней No 1: 660022, Красноярск, ул. – ГОУ ВПО "Новосибирский государственный медицинский университет", кафедра терапии факультета повышения квалификации и профессиональной переподготовки врачей: 630091, Новосибирск, Красный пр т, 52;. – У РАМН "НИИ терапии СО РАМН": 630089, Новосибирск, ул. I.I.Cherkashina, S.Yu.Nikulina, N.I.Logvinenko, V.A.Shulman, V.A.Shestovitsky, M.I.Voevoda, V.N.Maximov, A.A.Chernova

Summary

Материалы и методы

Результаты и обсуждение