Abstract
Background: Meningiomas are the second most common primary tumor of the central nervous system, with an incidence of approximately 30,000 new cases per year. However, there is a paucity of literature examining how healthcare, demographic, and socioeconomic factors impact patient survival outcomes. Methods: We conducted a retrospective study of patients from the National Cancer Database (NCDB) diagnosed with meningioma between 2004 and 2012. Univariate and multivariate analysis was performed to investigate the impact of patient, tumor, and treatment factors on overall survival: age, comorbidities, tumor behavior and size, and treatment strategy. Results: Diagnosis and treatment at an academic/research program, private insurance, female sex, Hispanic ethnicity, Asian race, higher median household income, and high school diploma conferred a survival advantage on both univariate and multivariate analyses of the 162,222 patients in the NCDB. Black race was associated with decreased survival on multivariate analysis. Conclusions: Disparities in survival outcomes in patients with meningiomas exist across multiple healthcare, demographic, and socioeconomic factors. Additional research is needed to elucidate the genetic and environmental factors driving these inequalities.
Highlights
IntroductionMeningiomas account for 37% of all primary central nervous system (CNS) tumors, with an incidence of approximately
Meningiomas account for 37% of all primary central nervous system (CNS) tumors, with an incidence of approximatelyMcCarthy et al [6], previously reported that age, tumor size, and treatment strategy were all predictors of meningioma patient survival [6]
Black race was not a significant predictor of survival on univariate analysis, it was significant in the multivariate model after correction for multiple comparisons (HR 1.10, confidence intervals (CI) [1.07-1.14] vs. white). This is a retrospective study on the impact of demographic factors on survival in patients with meningiomas based on 162,222 patients diagnosed between 2004 and 2012 using data available in the National Cancer Database (NCDB)
Summary
Meningiomas account for 37% of all primary central nervous system (CNS) tumors, with an incidence of approximately. McCarthy et al [6], previously reported that age, tumor size, and treatment strategy were all predictors of meningioma patient survival [6]. In another study specific to intracranial meningiomas, McKee et al, found that a higher CDCC score and advanced age, among other factors, were associated with. Given the lack of literature addressing the subject, the present study aimed to determine the effects of facility type, facility location, facility housing area, insurance status, ethnicity, race, sex, income, and education on meningioma patient survival. A retrospective study was conducted on 162,222 meningioma patients diagnosed between 2004 and 2012 using data available in the National Cancer Database (NCDB). Meningiomas are the second most common primary tumor of the central nervous system, with an incidence of approximately 30,000 new cases per year. There is a paucity of literature examining how healthcare, demographic, and socioeconomic factors impact patient survival outcomes
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