Inefficiency of ethanolic extract of Glycyrrhiza glabra and Ziziphus mauritiana roots on androgenic alopecia

Abstract

Aim: To study the air growth promoting effect of roots of G. glabra and Z. mauritiana in androgen (testosterone) induced male pattern baldness (androgenic alopecia). Materials and Methods: Animals were divided into four groups and they were attempted to made alopecic by treatment with testosterone for 3 weeks. Group 1 (control), 2 (standard), 3 and 4 animals (test) were also treated topically with vehicle, finasteride and ethanolic extract of Z. mauritiana roots and G. glabra roots respectively. Animals were observed for signs of alopecia and after treatment period one animal from each group was euthanized randomly and the skin sections from the treated area was examined for changes in follicular morphology. Statistical Analysis: Statistical analysis of data was carried out by one-way ANOVA. Using Instat version 2.1 software. Results: The Group 1, 3 and 4 animals develop alopecia and their skin section also shows bulbous and miniaturized hair follicles and prominent sebaceous gland while Group 2 (standard antiandrogenic drug finasteride treated) animals does not develop alopecia and skin samples also shows well-formed follicles and normal sebaceous gland. Conclusion: This experiments shows incapability of ethanolic extract of Z. mauritiana and G. glabra combating androgenic alopecia.