Abstract
Young male rats were divided into a control group and a group treated with lindane by addition of 60 ppm to the semi-synthetic diet for 4 wk. All the animals were then killed, half of each group after an 18-hr fast and the rest after a prolonged 72-hr fast. Ingestion of lindane accelerated the biotransformation of aminopyrine and of aniline by the liver microsomes and increased the P-450 content and the proportion of linoleic acid in the phosphatidylcholine. Prolonged fasting increased aniline hydroxylation and depressed aminopyrine demethylation. In lindane-treated rats, the fasting partly counteracted the induction of aminopyrine N-demethylase and of P-450 and completely suppressed the characteristic effect of the pesticide on the linoleic acid content of the phosphoglyceride. It is suggested that lindane treatment leads to the induction of a particular form of P-450 sensitive to starvation and bound in the membrane to a phosphatidylcholine rich in linoleic acid.
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