Abstract
Premature parturition was induced in goats by brief infusions of prostaglandin F 2α into uterine veins ipsilateral to the ovary containing the corpus luteum. Six-hour infusions at rates of 15, 7.5, 3.75 and 1.88 μg/min were luteolytic and consequently initiated labour. The lowest dose used (0.94 μg/min for 6 hours or 1.88 μg/min for 3 hours) caused no permanent change in circulating concentrations of progesterone and failed to initiate labour. Concentrations of Prostaglandin F in the utero-ovarian venous plasma resulting from infusions at rates of 1.88 and 7.5 μg/min were within the range of levels found previously in goats at the time of luteal regression preceding spontaneous delivery at term. All instances of luteolysis were followed by the delivery of live foetuses but all except one born 11 days prematurely died from respiratory failure. Lactation was established in 1 of the 5 does.
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