Abstract
Premature parturition was induced in five pregnant goats infused intravenously with 4.65–8.4 mg estradiol-17β but not in one treated with 5.85 mg estradiol-17α. A single intramuscular injection of 12 mg estradiol benzoate (8.8 mg estradiol-17β equivalents) was also effective. These doses were estimated to provide plasma concentrations of estradiol-17β in the physiological range for animals at spontaneous parturition. Circulating plasma concentrations of progesterone decreased and lactogenesis occurred before all instances of induced parturition but no such changes resulted from infusion of estradiol-17α. Placental delivery was normal in all animals but neonates of more than 10 days prematurity were non-viable. In three of the five goats infused with estradiol-17β, evidence was obtained for release of F-group prostaglandins from the uterus at the time of onset of the decline in progesterone.
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