Abstract
Mice of the CC57W strain were treated subcutaneouly with diamylnitrosoamine in a dose of 0.025 ml per mouse. once a week, 17 doses in all. These mice were sacrificed 27 weeks after the beginning of the experiment. Lung tumours, mainly adenomas, and in 3 cases adenocarcinomas, were detected in 14 of 17 mice which died and in 24 sacrificed mice. Besides, a marked proliferation of the interstitial tissue of the kidneys in a pretumor state, nephroblastoma, carcinoma in situ, and invasive cancer of the urinary bladder, one of each tumour, were found. Thus, diamylnitrosoamine can be recommended for induction of experimental lung tumours in mice.
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