Abstract
Long-term feeding studies were conducted in Sprague-Dawley rats using various dietary concentrations (up to 1000 ppm each) of nitrite and morpholine or 5 or 50 ppm N-nitrosomorpholine. The animals fed nitrite and morpholine at moderate to high concentrations developed hepatocellular carcinomas and angiosarcomas, histologically identical to those induced by preformed N-nitrosomorpholine. The data suggest that in vivo nitrosation of morpholine does occur in the rat, presumably in the acidic gastric environment.
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