Abstract
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) (Fig. 1) is the most potent carcinogenic nitrosamine so far found in tobacco and tobacco smoke (3). It induces lung, nasal cavity, liver, and pancreatic tumors in F344 rats; nasal cavity and lung tumors in hamsters; and lung tumors in mice (5). The organ-specific effect of NNK in the induction of lung tumors in all species tested supports its possible role in the development of lung cancer among smokers. Therefore, it is of great importance to discover compounds, either synthetic or dietary-related, which can counteract the carcinogenic action of NNK.
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