Abstract
Our previous study showed that methanolic extract of Inula helenium had potential to induce detoxifying enzymes such as quinine reductase (QR) and glutathione S-transferase activity in murine organs and cultured cells. Our study showed that sesquiterpenes, isolated from hexane soluble fraction, appeared to be responsible for QR induction. Among seven compounds tested in this study, alantolactone, isoalantolactone, and 5-epoxy alantolactone significantly induced QR activity in both Hepa1c1c7 and BPRc1 cells. In particular, alantolactone induced the activities of QR and GST in a dose-dependent manner. It also increased the expression of phase 2 detoxifying enzymes including QR, glutathione reductase, hemoxygenase-1, gamma-glutamylcysteine synthase. In conclusion, alantolactone present in Inula helenium merit further evaluation as chemopreventive agents.
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