Abstract
The treatment of choice for locally advanced resectable oral cavity cancer is surgery followed by (chemo)radiation. Two randomized phase III trials investigated induction chemotherapy followed by surgery in patients with squamous cell oral cavity cancers. These two trials did not demonstrate the superiority of the induction arms. However, patients with a clinical response or favorable pathologic response had a better outcome compared with patients with no or limited response to induction. A meta-analysis of these two trials suggested that induction chemotherapy could be useful for patients with clinical N2 disease. No randomized trials have properly investigated if induction chemotherapy before the loco-regional treatment in case of unresectable oral cavity cancer could be beneficial. Further clinical trials are needed to better define the role of induction chemotherapy in unresectable and resectable oral cavity cancer.
Published Version
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