Abstract
Introduction: Clindamycin is a commonly used antibiotic to treat skin and soft tissue infectionscaused by Staphylococcus aureus particularly Methicillin-Resistant Staphylococcus aureus (MRSA)infection. In vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycinresistance due to genes resulting in treatment failure, thus necessitating the need to detect suchresistance by a simple D - test on a routine basis. Materials and Methods: 165 isolates ofStaphylococcus aureus were subjected to routine antibiotic susceptibility testing including Oxacillin(1μg) and Cefoxitin (30μg) by Kirby Bauer disc diffusion method. Inducible clindamycin resistancewas detected by D test as per CLSI guidelines on erythromycin resistant isolates. Results: 24(14.5%) isolates showed inducible clindamycin resistance, 8 (4.84%) showed constitutive resistancewhile the remaining 59 (35.75%) showed MS phenotype. Inducible clindamycin resistance and MSphenotype were found higher in MRSA (21.42%, 40.47%) as compared to MSSA (7.40%, 30.86%).Conclusion: This study showed that the D test should be used as a mandatory method in routinedisc diffusion testing to detect inducible clindamycin resistance.
Highlights
Clindamycin is a commonly used antibiotic to treat skin and soft tissue infections caused by Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus (MRSA) infection
Inducible clindamycin resistance and MS phenotype were found higher in MRSA (21.42%, 40.47%) as compared to MSSA (7.40%, 30.86%)
This study showed that the D test should be used as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance
Summary
Clindamycin is a commonly used antibiotic to treat skin and soft tissue infections caused by Staphylococcus aureus Methicillin-Resistant Staphylococcus aureus (MRSA) infection. Conclusion: This study showed that the D test should be used as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance. Staphylococcus aureus (S.aureus) is recognised as one of the important organism causing hospitalacquired and community-acquired skin and soft tissue infections in most parts of the world. Clindamycin is considered a useful alternative in Penicillin allergic patients for the treatment of skin and soft tissue infections caused by S.aureus. It gets accumulated in abscesses and no renal dosage adjustment is required. Good oral absorption makes it an attractive option for outpatient prescription or as a follow-up drug after intravenous therapy [4]
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