Abstract
Besides disease condition, very few stress stimulants were determined to provoke red blood cell (RBC) adhesion to endothelial cells (EC). However, the possible role of other stress factors which disrupt RBCs anti-adhesive property is still unknown. To resolve this, we studied in vitro static adherence of RBC-EC after RBC exposure to physical (osmotic and shear stress) and chemical stress stimulants (cholesterol depletion and nitric oxide modulation). In support with earlier studies, RBC under hypertonic shock demonstrated a significant increase in RBC-EC adherence as a result of prominent structural modification. Besides, our study shows that shear stress, cholesterol depletion and nitric oxide inhibition in RBC increases RBC-EC adhesiveness which elucidates cholesterol, nitric oxide and shear stress importance in preventing RBC-EC adhesion. Thus, present study shows that assessment of RBC-EC interaction after exerting to external stress is critical in understanding pathophysiological conditions.
Published Version
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