Abstract
To investigate the effect of social isolation (SI) on spatial memory in rats from two experimental paradigms: Morris Water Maze (WM) and Barnes Maze (BM). Methods: 30 male Wistar rats were randomly assigned to three groups: G1, G2, and G3. G1 was maintained in the social condition (SC) from the beginning to the end of the study (± 200 days). G2 was submitted to induced social isolation (SI) until the end of the study, and G3, maintained in SI for 60 days, from its arrival and in a social condition (SC) until the end of the research (± 200 days). The spatial memory was evaluated at 90 and 200 days of life, using the BM and WM. Results: G1 shows better performance in the A test in both Phase I (g1 - f1) and Phase II (g2 - f2). G2 in both phases (g2 - f1; g2 - f2) was shown to be the group with the highest data dispersion, thus constituting the group with the worst performance during WM and BM in both phases (I and II). G3 (g3 - f1; g3 - f2) was constituted as an intermediate group in both tests and in both phases. Regardless of the group or stage, the subjects had worse performance in test B. Conclusion: Social isolation can generate negative impacts in terms of training and recovery of long-term spatial memory. Keywords: Space Memory, Induced Social Isolation, Recognition
Published Version
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