Abstract
Cell-based therapy for treating neurodegenerative diseases is a primary goal in regenerative medicine research that attracts tremendous attention. Advances in the direct lineage conversion of somatic cells into induced neurons (iNs) in vitro provides an interesting alternative to induced pluripotent stem cell (iPSC) based disease modeling. However, the innate limitations of iNs may restrict their applications in the clinic. Very recent publications describe the direct conversion of mouse somatic cells into induced neural stem cells (iNSCs)1,2,3,4,5,6. Together with other reports7,8, they constitute the basis for a rising concept that priming and retaining reprogrammed cells into an expandable neural progenitor stage may render them to be more amenable and with great potential for both disease modeling and possible therapeutic treatment for neurological diseases.
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