Abstract
Chronic obstructive pulmonary disease (COPD) is a chronic disease characterized by progressive airflow obstruction, along with pulmonary and systemic inflammation. Outdoor PM has been associated with morbidity and mortality in COPD but less is known about effects of indoor air quality. In former smokers with COPD, we investigated in-home PM effects on pulmonary and systemic inflammation, symptoms, and lung function. Participants underwent in-home air monitoring for two weeks and simultaneous health assessments. Median (IQR) PM2.5 was 9 (7) μg/m3. Increased indoor PM2.5 was associated with increased white blood cells, predominantly neutrophils and lymphocytes, suggesting that even relatively low indoor PM2.5 may elicit a systemic inflammatory response in COPD.
Highlights
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by progressive airflow obstruction with pulmonary and systemic inflammation that persists even after the inciting cause is removed [1] [2]
We found that increased indoor PM2.5 was associated with increased peripheral white blood cell count, predominantly neutrophils and lymphocytes in former smokers with COPD
It is noteworthy that this relationship between in-home particulate matter (PM) and systemic inflammation was detected in homes with relatively low indoor PM concentrations where environmental tobacco smoke was not the major source of airborne PM
Summary
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by progressive airflow obstruction with pulmonary and systemic inflammation that persists even after the inciting cause is removed [1] [2]. Other environmental exposures, such as outdoor air pollu-. (2015) Indoor Particulate Matter Associated with Systemic Inflammation in COPD. Exposure to outdoor particulate matter (PM) has been independently associated with respiratory exacerbations, hospital admissions, and mortality in those with COPD [5]-[9]. There has been increasing recognition of the potential health implications of indoor air quality. The impact of indoor air upon these predominantly home dwellers may be much greater than our current knowledge of the effects of ambient pollution. Evidence that indoor pollutants within homes in the United States may be contributing to respiratory morbidity in individuals with COPD, even in the absence of smoking, is limited. The effects of indoor air pollution exposure upon pulmonary and systemic inflammation are not well established
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
