Indomethacin (i.c.v.) reverse the inhibitory action of peptides on gastric secretion

Abstract

Central administration of diverse peptides, such as dermorphin (100 ng), salmon calcitonin (250 ng), human-corticotropin-releasing-factor (10 μg) and human-calcitonin-gene-related-peptide (10 μg) inhibited gastric acid secretion in pylorus-ligated rats. With the exception of salmon calcitonin this suppressive effect was significantly reversed by the central administration of 400 μg indomethacin. These data suggest that the gastric inhibitory effect of dermorphin, human-corticotropin-releasing-factor and human-calcitonin-gene-related-peptide might be mediated by the central synthesis of a cyclooxygenase product(s).