Abstract
Tubulin inhibitors are conjugates that interfere with the dynamic equilibrium of thepolymerization and depolymerization of microtubules. Among all the reported conjugates, indole moiety is one of the mostsignificant classes for the development of new drug candidates for cancer therapy. Due to their presence in a wide range of natural as well as synthetic antitubulin agents, indole has become a versatile scaffold in research, and various synthetic and semisynthetic indole-based antitubulin agents have been identified and reported. The present article focuses on the reported indole-based tubulin inhibitors of synthetic origin from last the decade. Synthesis, structure-activity relationshipsand biological activities of synthetic indole derivatives along with brief updates on theirantitubulin activity are presented.
Published Version
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