Abstract
To develop in direct colorimetric assay of pregabalin in commercial forms (capsules). This work is depend on the oxidation of pregabalin using an increasing of potassium iodate (KIO3) in presence of sulphuric acid medium is produced by the reaction of iodide ion which in turn reacts excess iodine. To release iodine and to make sure that we interact with starch we get an active complex gives maximum absorption 600nm. The calibration plot is linear in the conc. Range of 20-240 g.ml-1 with amolar absorptivity is 0.239x103 l/mol.cm. The (LOD) and (LOQ) are 0.0014 and 0.0048 µg.mL-1 respectively. The proposed method can be applied for the determination of pregabalin in pure and its capsules form.
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