Abstract
In patients with acne vulgaris – the inhabitants of the natural biogeochemical iodine deficiency region, changes in the immune system that indicate the formation of a secondary immunodeficiency state, mainly T-lymphocytes, and reduced phagocytic activity of phagocytic blood cells that are interdependent with the severity of clinical manifestations of dermatosis have been detected.
Highlights
Acne vulgaris is one of the most common skin diseases which is registered in 8090 % of teenagers and young working people [1, 7, 8]
It was established that acne vulgaris appears on the basis of genetic susceptibility due to irregularities of the sebaceous glands function, pathological desquamation of sebaceous follicle epithelium and activation of the skin flora (Propionibacterium acnes, Staphylococcus epidermis and others)
In determining the parameters of the immune system in 75 patients with acne vulgaris who permanently reside in natural iodine deficiency, we found (Table 1) signs of secondary immunodeficiency state, and mainly Tsuppressor lymphocytes (Ts)-cell population of lymphocytes
Summary
Acne vulgaris is one of the most common skin diseases which is registered in 8090 % of teenagers and young working people [1, 7, 8]. It was established that acne vulgaris appears on the basis of genetic susceptibility due to irregularities of the sebaceous glands function, pathological desquamation of sebaceous follicle epithelium and activation of the skin flora (Propionibacterium acnes, Staphylococcus epidermis and others). The changes in endocrine regulation, immune system as well as in metabolism contribute to the development of inflammatory processes in the skin. The changes in the immune system as well as the thyroid gland functional state, having multifaceted regulatory impact upon metabolic processes in the organism of patients proved to be important in the development and chronicity of dermatoses [1, 7, 2]. The study of the thyroid gland and systemic immunity condition in patients with acne vulgaris, living in a region with natural iodine deficiency is relevant
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