Indian contribution to design and development of SMEDDS

Abstract

The self-microemulsifying drug delivery system (SMEDDS) are one of the novel drug delivery systems. SMEDDS help in overcoming a number of formulation-related issues such as solubility, absorption, drug targeting etc. Indian scientists and acdemicians have made significant and substantial contribution to design and developments of SMEEDS. Lipophilic, anti-cancer, anti-hyperlipidemic, anti-viral drugs have been quite popular for development of SMEDDS. Approaches have been suggested and experimentally proven that SMEDDS in many cases have enhanced therapeutic profiles. SMEDDS for polyphenols have been developed. Pharmacokinetics and IVIVC potential of SMEDDS has also been discussed. The Indians community has worked on design and development of SMEDDS of synthetic drugs such as celecoxib, acyclovir, ritonavir, tacrolimus, exemestane, bicalutamide, valsartan, candesartan cilexetil, etc. have been developed. Similarly SMEDDS of natural origin drugs such as beta-Artemether, curcumin, lovastatin, atorvastatin, silymarin, paclitaxel, docetaxel, etoposide etc. have also been prepared. SMEDDS has been successfully tried for lymphatic targeting of drugs. Still, here are still more challenges ahead in SMEDDS formulation and development. The present article attempts to outline the contribution of Indians in this promising field.