Abstract
BackgroundPrevious reports regarding the predictive power of adiposity indices remain inconsistent, and longitudinal studies on this top are limited. The associations of hyperuricemia risk with changes in obesity status, as well as the joint effects of baseline adiposity indices and body adiposity change on hyperuricemia risk are not fully elucidated. This study aimed to explore the independent and joint associations of baseline adiposity indicators and body adiposity change with hyperuricemia risk among middle-aged and older population in China.MethodsA total of 2895 participants aged ≥ 45 years from the baseline survey of the China Health and Retirement Longitudinal Study were followed up for 4 years. Anthropometric parameters (weight, height, and waist circumference) and serum uric acid were obtained using standard devices. Adjusted odds ratio and 95% confidential interval were calculated to estimate the associations between predictor variables and hyperuricemia risk using multivariate logistic regression.ResultsOf the 2895 participants, 293 (10.12%) cases of hyperuricemia were identified. Increased baseline body mass index (BMI), waist circumference, and waist-height ratio (WHtR) were significantly associated with higher risks of hyperuricemia. A slightly greater but non-significant area under the curve value was observed for waist circumference (0.622) than for BMI (0.611) and WHtR (0.614) (P = 0.447). Compared to subjects with stable adiposity status, participants with weight loss of ≥ 4 kg or waist circumference loss of ≥ 6 cm had a 56% or 55% lower risk of hyperuricemia, and those with weight gain of > 4 kg had a 1.62-fold higher risk of hyperuricemia. Compared to those without obesity, participants with incident or persistent obesity were more likely to develop hyperuricemia. Additionally, regardless of stable or increased weight/waist circumference during follow-up, individuals with obesity at baseline had a higher risk of incident hyperuricemia.ConclusionThis study demonstrates that BMI, waist circumference, and WHtR equally predict the development of hyperuricemia, and weight loss and waist circumference reduction are favorable in preventing hyperuricemia.
Highlights
Previous reports regarding the predictive power of adiposity indices remain inconsistent, and longitudinal studies on this top are limited
This study demonstrates that body mass index (BMI), waist circumference, and waist-height ratio (WHtR) predict the development of hyperuricemia, and weight loss and waist circumference reduction are favorable in preventing hyperuricemia
Individuals who developed hyperuricemia were more likely to be older, male, current drinkers; were more likely to have hypertension, dyslipidemia, and stroke; were more likely to have greater BMI, waist circumference, WHtR; and were more likely to have a higher concentration of serum uric acid (SUA), total cholesterol, C-reactive protein, and serum creatinine at baseline (Table 1)
Summary
Previous reports regarding the predictive power of adiposity indices remain inconsistent, and longitudinal studies on this top are limited. This study aimed to explore the independent and joint associations of baseline adiposity indicators and body adiposity change with hyperuricemia risk among middle-aged and older population in China. Hyperuricemia, a metabolic disease due to disorder of purine metabolism, affects 13.3% of the general population in China [1], 21.3% in the U.S [2], and 25.8% in Japan [3]. Both genetic and environmental factors may account for the development and progression of hyperuricemia [4], the underlying pathological mechanisms remain incompletely elucidated. Interventions aiming to reduce BMI and waist-height ratio (WHtR) might be effective in lowering the incidence of hyperuricemia
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