Abstract
Aims/hypothesisWe aimed to quantify the associations between change in objectively measured sedentary and moderate-to-vigorous physical activity (MVPA) times and self-reported television viewing over 6 years and change in a clustered cardiometabolic risk score (CCMR), including and excluding waist circumference (CCMR without adiposity component, CCMRno adip), and its individual components, among the adult children of people with type 2 diabetes.MethodsIn 171 adults (mean ± SD age 42.52 ± 6.30 years; 46% men) with a parental history of diabetes (ProActive UK), physical activity accelerometer measures and self-reported television viewing were assessed at baseline and a mean ± SD of 6.27 ± 0.46 years later. Associations between change in sedentary time, MVPA time and television viewing and cardiometabolic risk and mediation by adiposity change were examined by multiple linear regression and the product of coefficients method, respectively.ResultsGreater increases in sedentary time (h/day) were associated with larger increases in clustered cardiometabolic risk (CCMR: 0.08 [95% CI 0.01, 0.15]; CCMRno adip: 0.08 [0.01, 0.16]) and triacylglycerol (0.15 [0.01, 0.29]), independent of baseline sedentary and MVPA times, change in MVPA time and other confounders. No evidence was found for mediation by change in waist circumference and BMI for the associations with CCMRno adip and triacylglycerol. Greater increases in MVPA time (h/day) were associated with larger decreases in waist circumference (−3.86 [−7.58, −0.14]), independently of baseline MVPA and sedentary times, change in sedentary time and other confounders. Television viewing was not independently associated with any of the cardiometabolic outcomes.Conclusions/interpretationIncreasing sedentary time is independently related to increasing clustered cardiometabolic risk and triacylglycerol in adults at high risk of developing diabetes. Strategies to prevent diabetes might target reducing sedentary time. Trial registration ISRCTN61323766Electronic supplementary materialThe online version of this article (doi:10.1007/s00125-013-3102-y) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
Highlights
Central obesity, dysglycaemia, dyslipidaemia and hypertension are closely related cardiometabolic abnormalities that cluster in a large proportion of the adult population worldwide
We aimed to estimate the independent associations between changes in objectively measured time spent sedentary, in moderate-to-vigorous physical activity (MVPA) and in self-reported television viewing over 6 years and changes in clustered and individual cardiometabolic risk factors in adults with a parental history of type 2 diabetes
Compared with those who were excluded, participants included in the current study were slightly more educated (p
Summary
Dysglycaemia, dyslipidaemia and hypertension are closely related cardiometabolic abnormalities that cluster in a large proportion of the adult population worldwide This cluster of factors substantially increases the risk of developing type 2 diabetes, as well as cardiovascular and other chronic diseases [1, 2]. Insufficient moderate-to-vigorous physical activity (MVPA) is a recognised contributor to elevated cardiometabolic risk levels [3] and has been targeted by lifestyle interventions in adults at high risk of type 2 diabetes. Such interventions have had limited success, resulting in relatively modest changes in MVPA [4]. Television viewing is a potentially interesting intervention target, it is only one aspect of sedentary time and its association with cardiometabolic risk may differ from that of overall sedentary time [7, 18]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
