Abstract
Background: Achilles tendinopathy is common in diabetes mellitus and makes the tendon susceptible to rupture. Achilles tendon rupture healing is impaired in diabetics. Stromal vascular fraction can be an alternative treatment for Achilles tendon rupture in diabetic tendinopathy. Methods: Eighteen rats were used in this experimental study and divided into three groups: group 1, normoglycemia; group 2, diabetes mellitus; and group 3, diabetes mellitus injected with stromal vascular fraction. After 2 wk, we evaluated the fibroblasts, capillaries, and collagen. Results: The number of fibroblasts and capillaries and the amount of collagen were increased significantly in group 3 compared to group 1 and group 2 (P<0.05). Conclusions: Stromal vascular fraction increased the number of fibroblasts, angiogenesis, and the amount of collagen. Thus, stromal vascular fraction improved healing of Achilles tendon ruptures in rats with diabetic tendinopathy.
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