Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct.

Abstract

HomeCirculationVol. 147, No. 2Increasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextIncreasing Mononuclear Diploid Cardiomyocytes by Loss of E2F Transcription Factor 7/8 Fails to Improve Cardiac Regeneration After Infarct Zhe Yu, PhD, Lunfeng Zhang, PhD, Paola Cattaneo, PhD, Nuno Guimarães-Camboa, PhD, Xi Fang, PhD, Yusu Gu, MS, Kirk L. Peterson, MD, Julius Bogomolovas, PhD, Cecilia Cuitino, PhD, Gustavo W. Leone, PhD, Ju Chen, PhD and Sylvia M. Evans, PhD Zhe YuZhe Yu Skaggs School of Pharmacy and Pharmaceutical Sciences (Z.Y., L.Z., S.M.E.), University of California at San Diego, La Jolla. *Z. Yu and L. Zhang contributed equally. Search for more papers by this author , Lunfeng ZhangLunfeng Zhang Skaggs School of Pharmacy and Pharmaceutical Sciences (Z.Y., L.Z., S.M.E.), University of California at San Diego, La Jolla. *Z. Yu and L. Zhang contributed equally. Search for more papers by this author , Paola CattaneoPaola Cattaneo Institute of Genetic and Biomedical Research (IRGB), UOS of Milan, National Research Council of Italy (P.C.). Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy (P.C.). Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany (P.C., N.G.-C.). German Center for Cardiovascular Research, Berlin (partner site Frankfurt Rhine-Main) (P.C., N.G.-C.). Search for more papers by this author , Nuno Guimarães-CamboaNuno Guimarães-Camboa Institute of Cardiovascular Regeneration, Goethe University, Frankfurt, Germany (P.C., N.G.-C.). German Center for Cardiovascular Research, Berlin (partner site Frankfurt Rhine-Main) (P.C., N.G.-C.). Search for more papers by this author , Xi FangXi Fang https://orcid.org/0000-0001-7816-8821 Department of Medicine (X.F., Y.G., K.L.P., J.B., J.C., S.M.E.), University of California at San Diego, La Jolla. Search for more papers by this author , Yusu GuYusu Gu Department of Medicine (X.F., Y.G., K.L.P., J.B., J.C., S.M.E.), University of California at San Diego, La Jolla. Search for more papers by this author , Kirk L. PetersonKirk L. Peterson Department of Medicine (X.F., Y.G., K.L.P., J.B., J.C., S.M.E.), University of California at San Diego, La Jolla. Search for more papers by this author , Julius BogomolovasJulius Bogomolovas Department of Medicine (X.F., Y.G., K.L.P., J.B., J.C., S.M.E.), University of California at San Diego, La Jolla. Search for more papers by this author , Cecilia CuitinoCecilia Cuitino Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus (C.C.). Search for more papers by this author , Gustavo W. LeoneGustavo W. Leone Medical College of Wisconsin Cancer Center, Department of Biochemistry, Medical College of Wisconsin, Wauwatosa (G.W.L.). Search for more papers by this author , Ju ChenJu Chen https://orcid.org/0000-0001-7674-4776 Department of Medicine (X.F., Y.G., K.L.P., J.B., J.C., S.M.E.), University of California at San Diego, La Jolla. Search for more papers by this author and Sylvia M. EvansSylvia M. Evans Correspondence to: Sylvia M. Evans, PhD, Medicine, 9500 Gilman Dr, BRF II, Room 2A16, University of California San Diego, La Jolla, CA 92093. Email E-mail Address: [email protected] https://orcid.org/0000-0001-5035-3697 Skaggs School of Pharmacy and Pharmaceutical Sciences (Z.Y., L.Z., S.M.E.), University of California at San Diego, La Jolla. Department of Medicine (X.F., Y.G., K.L.P., J.B., J.C., S.M.E.), University of California at San Diego, La Jolla. Department of Pharmacology (S.M.E.), University of California at San Diego, La Jolla. Search for more papers by this author Originally published9 Jan 2023https://doi.org/10.1161/CIRCULATIONAHA.122.061018Circulation. 2023;147:183–186This article is commented on by the following:A Tedious Journey: Cardiomyocyte Proliferation Requires More Than S-Phase Entry and Loss of PolyploidizationFootnotes*Z. Yu and L. Zhang contributed equally.For Sources of Funding and Disclosures, see page 186.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Sylvia M. Evans, PhD, Medicine, 9500 Gilman Dr, BRF II, Room 2A16, University of California San Diego, La Jolla, CA 92093. Email [email protected]edu