Abstract
Supercritical fluid extraction (SFE) conditions have been investigated in terms of mobile phase modifier, pressure, temperature and flow-rate to improve extraction efficiency. Extraction efficiencies of up to 100% in less than 2 h have been obtained. These extraction efficiencies resulted from our extensive parameter optimization experiments. Packed column supercritical fluid chromatography (SFC) has been used to examine the effect of these parameters on retention behavior. A relationship between chromatographic retention and extraction efficiency was sought. By determining trends of the chromatographic capacity factors using SFC conditions corresponding to SFE parameters, a prediction of extraction efficiency can be made. These predictions have shortened method development time in SFE.
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