Abstract
Increased Vitamin D Signalling Markers in the Skin of Atopic Dermatitis Patients
Highlights
Serum vitamin D levels have been described to be positively or negatively affected in atopic dermatitis [1,2,3,4]
In addition the vitamin D receptor (VDR) can heterodimerize with the retinoid X receptor (RXR) which ligands [7,8,9] were associated with positively influencing VDR-RXR-mediated signalling [10,11]
Just limited AD-relevant target organs like the skin and the immune system were examined for vitamin D-mediated signaling during allergic sensitization, chronic manifested atopic dermatitis and after vitamin D-supplementation studies [12,13,14]
Summary
Serum vitamin D levels have been described to be positively or negatively affected in atopic dermatitis [1,2,3,4]. Endogenous serum as well as skin concentrations of the endogenous bioactive vitamin D receptor (VDR) ligand 1,25-dihydroxy-vitamin D3 (1,25VD3) are hard to determine using analytical techniques due to the low endogenous levels in the range of 10-12M [5]. Polymorphisms of the VDR are present in patients with severe AD indicating a strong association of vitamin D-mediated signaling and AD [6].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
