Abstract
Isoprostanes, novel markers of oxidative injury, are generated by the free radical-mediated peroxidation of arachidonic acid (AA). They are thought to be important in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD). Using gas chromatography–mass spectrometry (GC–MS), we investigated the alteration of urinary F 2-isoprostanes in AD patients compared to that of healthy subjects. Our results show that the levels of urinary F 2-isoprostanes, sum of the prostaglandin F 2α isomer; prostaglandin F 2α (PGF 2α), prostaglandin F 2β (PGF 2β), and 8-isoprostaglandin F 2α (8-isoPGF 2α), significantly increased in AD patients ( P < 0.05). The concentration of urinary 8-isoPGF 2α, one of the biomarkers of oxidative stress, was not significantly different between 34 AD patients and 20 age-matched controls ( P > 0.05). The PGF 2α, formed by endoperoxide reductase from PGH 2, was significantly increased in AD patients, when compared with the levels of the normal controls ( P < 0.05). The PGF 2α, an enzymatic product of arachidonic acid, may affect the pathogenesis of AD. In addition, urinary F 2-isoprostanes can play an important role as a biomarker in AD.
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