Abstract
BackgroundEndoglin is involved in the regulation of endothelial function, but there are no studies concerning its relation with hypertension- and diabetes-associated pathologies. Thus, we studied the relationship between plasma levels of soluble endoglin and cardiovascular alterations associated with hypertension and diabetes.MethodsWe analyzed 288 patients: 64 with type 2 diabetes, 159 with hypertension and 65 healthy patients. We assessed the relationship of soluble endoglin plasma levels measured by enzyme-linked immunosorbent assay with basal glycemia, glycosylated hemoglobin, blood pressure, endothelial dysfunction (assessed by pressure wave velocity), hypertensive retinopathy (by Keith-Wagener classification), left ventricular hypertrophy (by Cornell and Sokolow indexes), cardiovascular risk and target organ (heart, vascular, kidney) damage.ResultsThere are significant correlations between endoglin and glycemia, systolic blood pressure, pulse pressure, pressure wave velocity and electrocardiographically assessed left ventricular hypertrophy. Endoglin levels were significantly higher in patients with diabetes who had nondipper and extreme dipper circadian blood pressure patterns than in dipper circadian patterns, in patients with hypertension and diabetes who had riser pattern than in the other patients, and in patients with diabetes but not hypertension who had extreme dipper pattern than in dipper, nondipper and riser groups. There was also a significant correlation between plasma-soluble endoglin and lower levels of systolic night-day ratio. Higher endoglin levels were found in patients with diabetes who had retinopathy, in patients with diabetes who had a high probability of 10-year cardiovascular risk, and in patients with diabetes and hypertension who had three or more damaged target organs (heart, vessels, kidney) than in those with no organs affected.ConclusionsThis study shows that endoglin is an indicator of hypertension- and diabetes-associated vascular pathologies as endothelial dysfunction and cardiovascular damage.
Highlights
Endoglin is involved in the regulation of endothelial function, but there are no studies concerning its relation with hypertension- and diabetes-associated pathologies
Endoglin levels were higher in patients with hypertension and diabetes with riser circadian pattern than in the other patients (Figure 1B)
Our data shows that Sol-endoglin plasma levels are significantly related to glycemia, systolic blood pressure (SBP), pulse pressure, Pulse wave velocity (PWV), heart rate and the degree of left ventricular hypertrophy (LVH) assessed by ECG
Summary
Endoglin is involved in the regulation of endothelial function, but there are no studies concerning its relation with hypertension- and diabetes-associated pathologies. Endoglin ( known as CD105), a type I transmembrane glycoprotein highly expressed on proliferating vascular endothelial cells (ECs) [7], has been identified as an accessory receptor for transforming growth factor-b (TGF-b) [8] It is expressed as a 180-kDa homodimer formed by disulfide-linked monomers [9]. A soluble form of endoglin plays a central role in preeclampsia, a disease characterized by hypertension and severe alterations in placental circulation [15]. Overall, these data support the view that endoglin has a pivotal function in vascular development and disease [13]
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